Current concept of biological knee reconstruction in Japan

 大槻 周平先生

1. Curriculum vitae
Name Shuhei Otsuki
Date/Place of Birth July 24, 1972; Kyoto, Japan
Position Assistant Professor
Institution Osaka Medical College
 Department of Orthopedic Surgery
 2-7 Daigakumachi Takatsuki Osaka, JAPAN 569 - 0007
Phone: +81(72) 683 - 1221
Email: Otsuki.shuhei@gmail.com
Degree Year Conferred Field of Study
 M.D. 1998 Orthopedic Medicine
 Ph.D. 2008 Orthopedic Medicine

Education and Professional Experience
1992 – 1998
1998 – 1999
2003 – 2007
2007 – 2008
2008 – 2010
2011 –
Medical School, Osaka Medical College
Department of Orthopedic Surgery, Osaka Medical College, Japan
Osaka Medical College Graduate School, Japan
Research Associate, The Scripps Research Institute, La Jolla, CA, USA
Senior Research Associate, The Scripps Research Institute, La Jolla, CA, USA
present Assistant Professor
Department of Orthopedic Surgery, Osaka Medical College


Postdoctoral Fellow of Arthritis Foundation in USA ( - 2010)
Japan Orthopedic and Traumatology Foundation Award
115th The Central Japan Orthopedic Trauma society Award
17th The Japan Society of Cartilage Metabolism Award
The Nakatomi Foundation Award
The Uehara Memorial Foundation Award

2010 - 2012

2012 - 2015

2015 - 2018
Research Activity Start-up of Japan Society
for the Promotion of Science (¥1,440,000)
Grants-in-Aid for Young Scientists (B) of Japan Society
for the Promotion of Science (¥4,290,000)
Kiban (C) of Japan Society
for the Promotion of Science (¥4,790,000)

2. List of publications




















Otsuki S, Kin A, Abe M. Intraosseous Schwanoma of 4th Lumbar Vertebra. A case report. Clinical Orthopaedic Surgery 2001(5) 685-9.
Otsuki S, Kishimoto I. Radiographic Study of Hydroxyapatite and Tricalcium Phosohate Coating Sockets on Cementless Total Hip Arthroplasty. The Central Japan Journal 2003 (46) 207-8.
Otsuki S, Horiguchi Y, Inoue T. A Statistics study of Intertrochanteric Hip Fracture with the ACE Captured Hip Screw System. Fracture 2005 (27) 573-6.
Otsuki S, Nakajima M, Lotz M, Kinoshita M. Hyaluronic Acid and Chondroitin Sulfate Content of Osteoarthritic Cartilage: Site-specific correlation with weight-bearing force based on femorotibial angle Measurement. J Orthop Res 2008 (26) 1194-8.
Otsuki S, Brinson D, Creighton L, Kinoshita M, D’Lima D, Lotz M. The impact of Glycosaminoglycan Loss on Chondrocyte Viability. Arthritis Rheum. 2008 (58) 1076-85.
Otsuki S, Taniguchi N, Grogan S, D’Lima D, Kinoshita M, Lotz M. Expression of Novel Extracellular Sulfatases Sulf-1 and Sulf-2 in Normal and Osteoarthritic Articular Cartilage. Arthritis Res Ther. 2008 R61.
Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz M, Asahara H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates IL-1 responses. Arthritis Rheum, 2009 (60) 2723-30.
Otsuki S, Grogan SP, Miyaki S, Kinoshita M, Asahara H, Lotz M. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage. J Orthop Res, 2010 (28) 96-102.
Caramés B, Taniguchi N, Otsuki S, Blanco FJ, Lotz M: Autophagy is a Protective Mechanism in Normal Cartilage and its Aging-related Loss is Linked with Cell Death and Osteoarthritis. Arthritis Rheum, 2010. Mar;62(3):791-801.
Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S,Takada S, Lotz MK, Ueno-Kudo H, and Asahara H. Targeted disruption of cartilage-specific microRNA140 promotes osteoarthritis-like pathology: Gene Dev, 2010. Jun 1;24(11):1173-85.
Otsuki S, Hanson SR, Miyaki S, Grogan SP, Asahara H, Kinoshita M, Lotz MK. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways: Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10202-7
Lotz MK, Otsuki S, Grogan SP, D’Lima DD. Cartilage cell clusters: Arthritis & Rheum, Arthritis Rheum. 2010 Aug;62(8):2206-18. Review
Schelwies M, Brinson D, Otsuki S, Hong YH, Lotz MK, Wong CH, Hanson SR. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases. Chembiochem. 2010 Nov 22;11(17):2393-7.
Pauli C, Grogan SP, Patil S, Otsuki S, Hasegawa A, Koziol J, Lotz MK, D'Lima DD. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage. 2011.Sep;19(9);1132-41.
Hasegawa A, Otsuki S, D’Lima DD, Koziol J, Lotz MK. Histopathology of the human anterior cruciate ligament in aging and osteoarthritis. Arthritis Rheum, (63) 2012. Mar;64(3):696-704.
Otsuki S, Nakajima M, Oda S, Hoshiyama Y, Fujiwara K, Jotoku T, Neo M. Three-dimensional transfer of the tibial tuberosity for patellar instability with patella alta. J Orthop Sci. 2013. May;18(3):437-42.
Otsuki S, Nakajima M, Okamoto Y, Oda S, Hoshiyama Y, Iida G, Neo M. Correlation between Varus Knee Malalignment and Patellofemoral Osteoarthritis Knee Surg Sports Traumatol Arthrosc. 2014 in press
Hoshiyama Y, Otsuki S, Oda S, Kurokawa Y, Nakajima M, Jotoku T, Tamura R, Okamoto Y, Lotz MK, Neo M.Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells. J Orthop Res. 2015 Apr;33(4):548-55.
Oda S, Otsuki S, Kurokawa Y, Hoshiyama Y, Nakajima M, Neo M.A new method for meniscus repair using type I collagen scaffold and infrapatellar fat pad. J Biomater Appl 2015 May;29(10):1439-48.
Otsuki S, Nakajima M, Fujiwara K, Okamoto Y, Iida G, Murakami T, Neo M.Influence of age on clinical outcomes of three-dimensional transfer of the tibial tuberosity for patellar instability with patella alta. Knee Surg Sports Traumatol Arthrosc. 2016 Feb 2. [Epub ahead of print]
Okamoto Y, Otsuki S, Jotoku T, Nakajima M, Neo M. Clinical usefulness of hindfoot assessment for total knee arthroplasty: persistent post-operative hindfoot pain and alignment in pre-existing severe knee deformity. Knee Surg Sports Traumatol Arthrosc. 2016 Apr 7. [Epub ahead of print]

3. Letter of motivation/career goals.
Since the start of my Ph.D. program, I have had an interest in OA mechanism with cartilage homeostasis. My Ph.D research was glycosaminoglycan (GAG) concentration with knee alignment, and clarified no indication of high tibial osteotomy for severe varus knee based on the GAG concentration (JOR 2008). Subsequently, I went abroad to determine the mechanism of OA at The Scripps Research Institute for 3 years. Professor Martin Lotz supported my researches on GAG loss and chondrocyte biology (A&R 2008), and the effect of heparan sulfate endosulfatase (Sulf) for OA (AR&T 2008, PNAS 2010).
Since 2011, I have been working on biological knee reconstruction and have continued cartilage related research in my roles as an assistant professor in Osaka Medical College. My short-term goal is to establish translational research from bench to bedside, particularly as it applies to biological reconstruction of the knee.
As related to the clinical side, I am very interested in patellofemoral (PF) instability. I recently reported on a new surgical procedure for patellar instability with patella alta in this year (JOS 2013). Of particular interest to me is the study of cartilage degeneration in the PF joint. It is my desire to learn good surgical techniques and gain a biological understanding particularly of the cartilage degeneration with PF joint.
In basic part, researches with the graduate students about meniscus remodeling and the effect of intra-articular Sulf injection for OA knee were accepted at next ICRS congress in Izmir. My previous research continues through collaborations with Prof. Martin Lotz and investigating the possibility of Sulf for chondrocyte protective effect.
My long-term goal in combining my clinical and basic research experience would be identify a novel and evolutionary cartilage tool, which will benefit patients and society.


第17回 日仏整形外科学会